Papini’s primary research area in the field of psychology how the brain processes emotions—particularly frustration. He works with rodents because their brains are similar to those of humans.
“We focus on the basal ganglia, which is a complex brain circuit,” he said. The basal ganglia (or “BG” for short) are particularly engaged when an animal undergoes some sort of emotional activation.
In the lab, Papini conducts experiments with a series of standardized tasks to understand the neurological basis behind the emotion of frustration. “The tasks usually involve giving rats something good—or something they really like—such as a sugar solution,” he said.
He gives the rats a reward—usually a concentrated sugar solution—for many days so that the rodents grow to expect the sweet treat. Then, Papini dilutes the solution. The animals reject it. “The rejection is accompanied by an emotional stress response [frustration], and this is what I am trying to understand: What makes the rat reject it under the expectation of receiving something better?”
Papini noted that this experimental setup is a good model for a number of types of research, including anxiety and addiction.
In future stages of the experiment, Papini will work alongside specialized neurosurgeons to test specific brain sites to monitor rats' reactions and gain a better understanding of their underlying brain circuitry. “There is nothing, as far as I can tell, more complicated than the brain of a mammal,” he said.